Supplementary Material from: Association between markers of adiposity during childhood and puberty onset in Latino girls. (doi:10.34691/UCHILE/JMPKHP)

View:

Part 1: Document Description
Part 2: Study Description
Part 5: Other Study-Related Materials
Entire Codebook

Supplementary Material from: Association between markers of adiposity during childhood and puberty onset in Latino girls.

doi:10.34691/UCHILE/JMPKHP

Repositorio de datos de investigación de la Universidad de Chile

2023-05-11

1

Pereira, Ana; Ferrer, Pedro; Binder, Alexandra; Rojas, Joanna; Michels, Karin; Corvalán, Camila; Meriq, Verónica, 2023, "Supplementary Material from: Association between markers of adiposity during childhood and puberty onset in Latino girls.", https://doi.org/10.34691/UCHILE/JMPKHP, Repositorio de datos de investigación de la Universidad de Chile, V1

Supplementary Material from: Association between markers of adiposity during childhood and puberty onset in Latino girls.

doi:10.34691/UCHILE/JMPKHP

Pereira, Ana (Institute of Nutrition and Food Technology, University of Chile, Santiago Chile)

Ferrer, Pedro (Institute of Nutrition and Food Technology, University of Chile, Santiago Chile)

Binder, Alexandra (Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaiʻi Cancer Center, Honolulu, USA; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA)

Rojas, Joanna (Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Atacama, Copiapó, Chile)

Michels, Karin (Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA; Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany)

Corvalán, Camila (Institute of Nutrition and Food Technology, University of Chile, Santiago Chile)

Meriq, Verónica (Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago, Chile.)

Repositorio de datos de investigación de la Universidad de Chile

Mericq, Verónica

Pino León, Constanza

2023-05-10

https://doi.org/10.34691/UCHILE/JMPKHP

Medicine, Health and Life Sciences, Peak Height Velocity, Menarche, Pubarche, Thelarche, Growth

Context: Prepubertal adiposity is associated with earlier puberty. It is unclear when this association starts, if all adiposity markers are similarly associated, and whether all pubertal milestones are similarly affected. Objective: To evaluate the association between different adiposity markers during childhood and the timing of different pubertal milestones in Latino girls. Design, setting and participants: Longitudinal follow-up of 539 female participants of the Chilean Growth and Obesity Cohort (GOCS) recruited from childcare centers (mean age 3.5y) from the South East area of Santiago, Chile. Participants were singletons born between 2002-2003 within the normal birthweight range. Since 2006, a trained dietitian measured weight, height, waist circumference (WC) and skinfolds to estimate BMI CDC percentiles, central obesity, fat mass (%FM) and fat mass index (FMI = fat mass/height2). Main Outcome: since 2009, sexual maturation was assessed every 6 months to assess age at: i) thelarche, ii) pubarche, iii) menarche, and iv) age at peak height velocity (PHV). Results: At thelarche, 12.5% were obese and 2% had central obesity. The median age of pubarche, menarche, and PHV were all associated with markers of adiposity at different time points during childhood; whereas thelarche only with %FM and FMI. Adiposity clusters models showed that children with trajectories of high WC, %FM and FMI during childhood were related with earlier thelarche, pubarche, menarche and PHV; BMI trajectories only with menarche and PHV. Conclusions: Higher WC, %FM and FMI were associated with earlier age at thelarche, pubarche, menarche, and PHV. The effect of BMI was less consistent.

Pereira A, Ferrer P, Binder A, Rojas J, Michels K, Corvalán C, Mericq V. Association between markers of adiposity during childhood and puberty onset in Latino girls. JCEM [under review] 2022.

Label:

Supplemental Figure 1.pdf

Text:

Supplemental Figure 1: Survival curves of age at thelarche onset stratified by different adiposity markers: a) Body Mass Index, b) Waist circumference, c) % of Fat Mass, d) Fat Mass Index

application/pdf

Label:

Supplemental Figure 2.pdf

Text:

Supplemental Figure 2: Survival curves of age at pubarche onset stratified by different adiposity markers: a) Body Mass Index, b) Waist circumference, c) % of Fat Mass, d) Fat Mass Index

application/pdf

Label:

Supplemental Figure 3.pdf

Text:

Supplemental Figure 3: Survival curves of age at menarche onset stratified by different adiposity markers: a) Body Mass Index, b) Waist circumference, c) % of Fat Mass, d) Fat Mass Index

application/pdf

Label:

Supplemental Figure 4.pdf

Text:

Supplemental Figure 4: Survival curves of age at peak height velocity stratified by different adiposity markers: a) Body Mass Index, b) Waist circumference, c) % of Fat Mass, d) Fat Mass Index

application/pdf

Label:

Supplementary Table 1.pdf

Text:

Supplementary Table 1: Hazard Ratio and 95% CI of BMI CDC percentiles between age 2 to 8 and different age of pubertal milestones (B2, P2, menarche, PHV)

application/pdf

Label:

Supplementary Table 2.pdf

Text:

Supplementary Table 2: Hazard Ratio and 95% CI of central obesity (according to Fernandez, >90th vs <90th) between age 4 to 8 and different age of pubertal milestones (B2, P2, menarche, PHV)

application/pdf

Label:

Supplementary Table 3.pdf

Text:

Supplementary Table 3: Hazard Ratio and 95% CI of % fat mass (skinfolds between age 4 to 8 and different age of pubertal milestones (B2, P2, menarche, PHV)

application/pdf

Label:

Supplementary Table 4.pdf

Text:

Supplementary Table 4: Hazard Ratio and 95% CI of % fat mass / Height2 (skinfolds between age 4 to 8 and different age of pubertal milestones (B2, P2, menarche, PHV)

application/pdf