10.34691/UCHILE/UYC3URBarbara Bruna JaraBarbara BrunaJara0000-0001-7356-4382Universidad de ChileJamileth MoreJamilethMore0000-0002-2071-1868Universidad de ChilePedro Lobos ZambranoPedroLobos Zambrano0000-0002-0831-1079Universidad de ChileDaniela Paz Ponce de la VegaDaniela Paz dece de la Vega0009-0009-0426-2562Universidad de ChileClaudia Duran-AniotzClaudiaDuran-Aniotz0000-0003-2503-8366Universidad Aldolfo IbañezJose Luis ValdésJose LuisValdés0000-0002-9178-2743Universidad de ChileMaria Alejandra GleisnerMaria AlejandraGleisner0000-0002-4172-9709Universidad de ChileFabian TempioFabianTempioUniversidad de ChileFelipe SalechFelipeSalech0000-0003-1575-7658Universidad de ChileMatías PizarroMatíasPizarroUniversidad Aldolfo IbañezCarol D SanMartínCarolD SanMartín0000-0003-3733-5448INTAMartín CárcamoMartínCárcamoCICAAndrew QuestAndrewQuest0000-0001-8755-1590Universidad de ChileMercedes LopezMercedesLopez0000-0002-1744-2038Universidad de ChileFlavio Salazar OFlavioSalazar O0000-0002-1848-5697Universidad de ChileMaria Isabel BehrensMaria IsabelBehrens0000-0003-0964-426XUniversidad de ChileMelanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model of Alzheimer’s diseaseRepositorio de datos de investigación de la Universidad de Chile2025Medicine, Health and Life SciencesAlzheimerCancerMaría Isabel BehrensMaría IsabelBehrensCICA_HCUCH2025-12-022025-12-091982875151621621621621621621621621621621621621621621621621621621621621623892786390652717757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772674866936245866787006843411151312961101196917757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734215921429052157177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734193617401732215620224526440713318985448140987954013127917757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773415241080214913341775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726897194617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773421252099177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577342155214921622022502687381360058594713810994111339872022452639361322178527613872396041300951528217817757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773419412156172419371775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241949150813291742202244263523131643851671371569454129549203241263686131993843911377509335130128215621471775772417757726177577261775772417757726177577241775772617757724177577241775772617757724177577261775772617757724177577241775772617757724177577261775772617757724177577241775772417757724177577241775772417757724177577241775772417757724177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775772617757726177577261775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734214221491736173617757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577342022482686691327168530513982692401308052032432696321338948539714001995921318269351585417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775772463802830289886370497100006681297140686805717229201077559675737792179490646638602884443659257775810116774127760166633187799805737873086743823707698387622792787173075370653099615582352882128971977807723488649882870691446791185088738707328267750884558975787192629367683092511666636671882480884536652561532733876320583729881766755796108718429959079433859748593773278686908904865099638826106262081698637607067988715909762285491707397577999805752376736385301746468033072759638538429166962757938917167340642087649671423930666964671667912946607770877819368111591698701158020668805709376519294784104740951236909182077730039096379811963897667363746919797137467661786439008385535861508858281991703766440470555913559334188264703086081066349768716995978160879107875869056633828888868658774098147985985708117502892806879479393387771657028143884676684628419570756711197753870914651347554375898708937135078561638688245072653702649837683428655547852367291667228961576938753088895481011691016957968999811186739110282892190653548083568030901469837991749862079029766235680486492574514735178743891562761328909265918839966944175595898326846485290850808662766821782117871290003700977860367941773677073582394804158133585565774708173090361722358172768901728709389488559735248530179971695079999072025686887435587389801777076169312664267332294482712938064964397684627921474553731316945967280788028643775230781597208190405853367717771557781916565868999666408169181877795396683288516747299595896472654108457387744854638784581243662557081869931715196969979509875728295676937693197172876413769338850972779657667791684906905756590575228646749578569375891497700966224728806593481315634819458794843691017056379273819606748274959673818929775888660597176196860852097665210452573898627536769175883802846915269407693838497673864658407910496375708718056472415834116728676091615836472067242705787398073936639767639694171629219787073550841607714162795663808042176244729616906384795671718306783899728287603094983840347465286553756818270079853667967741270274901128477470011692788723274493692881019581082401135259302012133812731399598118515131932110555118322105183118110120825111137118980908359017912263186754106364103888113690108777129970112375998401060401081021130131068109188911266010809289190110900916511102979612785193129848929788481711154911633194776120916982631011021181249050612618094528126983942161139641130481035728633910247484424882291095758640711697311983599185888609958011188492497111219102677108478938119812092109867188671090583976468809112494510336090640126168111777100535869838876698107120154109373110772933119359195394103127988929831593171119199965111053289902210450710494012767712210613210197030920291362221214619116090295113392965861127081157371167149762211908888183109335115472103036109968875311233111101799523510482988473118341111361118733941471072421137501045299234010443193055107502124322953661062839782310388011662783614119140112968120127125294963721144629332090766933309206110644411761611365810560810554010838491759117491961031230491026699263687377941949372811460496244131118986611133991050439709094160129034981041125019119210689898465934509208698409103679111838881679058710960011080711233611018993022993771083749265912223610948310311510340292334901649214811671091140116588127880955101233941052208914511473511579990432117442109042954621158841036821010269499511702910562512169193979106465112172115025100508108864120290919361016059499294733883391047859093912202893702113653950109457511157097616926879250794050107838100796103024100056106872113311104455117232107450983871054311088409664097354113967986411305041185371212989792797136947331054711033811144091028741034561157111270111053631181749160299788119006955081118431033159454410111198972948228961111326189580990239351710944387701116177103463127197112133950909136811179311094612246810712091454116313997139099111237910761395070981081064889101412504288438899149788395235853141068701364258953390436996599171297958936469039094449113458104963981329962790485111173982641213818632912177310478410524310206810217193654105899904889537893607119797913721257301104431068641106801114871212738923210335794618913289896991172115075111103115555105074978431135841022031042019908510432210578288844904371030481133049555311051610198996588112386122185110963946669443812999299312876948700190850101876925361026811000669630263154823268294756637107888897018262879018846639618895190618281026897543887755868871122058166098277888171310289882710760391975118082105237124031101711928537458310778581801118926911141045085224399943119142126078791541132957373691228130820564259607496638109278110262106964962158273310011190174100958789068960179644741216091611666073441488468585375662693717676112787976888452256716068279491451105745449274129781567132054129124890836317954412460611029581357710915761811212885196744651096587417965112837016758799686618541007669168794324759105691410503358898685918358871516914441065541025229688412639576974654359879185752728128318064519846131031315811099547542745168695881103213589751231636943510003510122885215998466239174079387528552868666793638681211321511438491690947171052767183411288673031114264614136841810054789755100133706196716510552277202100304964557062276677772428563269173112125612896597975364592279955360647848088318780483108571708837552079233896777006759560561261147451088131008187853793164623727332747272558217056011100510131480843753238815789545867811035366487378710885349791082624713234896563042106537690456808312313910442592065106522828856325611435585824937787280910847511308584806577925968561712628668902753575619099453297069849495340882290596349241611664170975936319988570386577729595568445810346056811053275209937911131558719590698627929162783253555631028318402778931967911095469668059845111780844311044639225553158963648680210333798525942889504097368508006885163663116000113568105841753968321595775656418742293424113542662018866110137345214830851325989127773370988209412581716897368629863211103912107609885421103307860198503877596846073390111778930797462110783563929699986573779921648641021287174411168858204893521206059522851256484187955965814100119114657866277242550244567481322998587559064811149195491470104040584915960663616580281141159291993511818201213527069168202912717109088265116110503551173665727752559754166541499802112916927291050146422011653265642717988740285198983829824385431650056195980189697967408061446113189786651091766601996890954529540359810908758371265030101385104272748326726884218108392508666938855509828102202521471539214921332159402177721424024024024024024024024024024024024024024024024024024024024024024021775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775772217757722177577221775772217757722177577221775772217757722177577221775772217757722177577241775772417757724177577241775772417757724177577241775772417757724177577241775772417757724177577241775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577341775773417757734177577241775772417757734177577341775773417757734177577341775773417757734177577341775773417757734203866306352364878695539271242635311638746569702685227033980953211266270982670726793114025733117821039962302710659051192347622001841726685403513126260461092026631269251670141622101088612454726169268982652526457269182642525477225991904827027261021869270972729626738903013797271802687342782650318149270182657227225861227922270992660426831254482660041092392239712687044831971827207272922686415225271041423410679270832675611388337456817326204812086969576447279442709926941268362606826419250199450230462640325182273372660126838773117205267113967233514342263422693615003679218508229822668124635597326195270572039125921271211329186111228341392591871326901254522738527279271431771326931105131491619784268552707027053268699995639814172273732852267652626716897106452715526939279965035051269522702927243270902678091576040658615162274471446926824269412629513505269802637016051954534612250758924651267322698126044962522567268162601857342705258144168145512711180007012270279170215852040127973270668002265292752026905591726484267302704412525434226800171172343572202687192232720325805238222696917347190022834188511638127476201941862518497256159318486325777195341565727178136352650514818126446607128667107104782006026102604325914213132668274762291117438225662719326586134219138245396659104831011612875102638370268917382267131768225873262831066627178262552672826655127122706627260272632658426161817927264258462419767512697926500215905463262691610086692196812109274992699944791564725448272672713326922258591461526992255516553200444137425526996129802732156661953513583510117989179671178416888707988812548127285639363231724027170275422692948735311265081711129225939863210817272252582362501719613419131442627027930271361719665679122158533442642626539269541017033663889268212697965915310534413670258221564045839762185936564276911191526894266132117023015265381414361862717060264014410619426893826608259023806129102684226646679827127261523191105492409853902668617767217921565727235582385046125291612063562194772125317612312681264930412649248119685212759952117654813180712135291220715402027776720356123725641237248811949081324759611986161244307212251482205392119022812587076125870481193720161665561203620124706681213196221517212158601829189618291904118850014909836118738412984016117258820585762000972119242414885716148857081188356177033281212872126626681203692204765220899921194152161280601612803211966361749135611884641450754811828842106272121690413344160138525848136368338220224328879613417684940168073106601322732022482891821344978491216714110084132484201201246245288576289305135187133902850888462516062716102299499663132028133248202244269663134467852911490859148132461201250267832134443852891361891002413239220220224824726828326714713553413404084762854471382771392219425978213203813357420220124724226544926804513436113373185563855671407061391959132917013178113234920124426883113512285517139166951813310620324626850913559485168138442965913357020224726762813513784978138111982413312420324926850813485485946138405960013293820124326651613257583749139971963013055520225026790213474685466143400943713284420024626697913538785275136965955613332019828216689977207958540238688722121text/tab-separated-valuestext/tab-separated-valuesapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamimage/jpegimage/jpegimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/tab-separated-valuestext/tab-separated-valuestext/tab-separated-valuesapplication/ziptext/tab-separated-valuestext/plaintext/plaintext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plainapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plainapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-mattext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plainapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-mattext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-mattext/tab-separated-valuestext/tab-separated-valuesimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegimage/jpegapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheettext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plainimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetimage/jpegapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheettext/tab-separated-valuesapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcsapplication/vnd.isac.fcstext/tab-separated-valuesapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-matapplication/matlab-matapplication/matlab-matapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/x-xfigapplication/matlab-mattext/tab-separated-valuestext/plaintext/tab-separated-valuestext/tab-separated-valuestext/tab-separated-valuestext/plainimage/jpegtext/plain2.0CC-BY 4.0The inverse association between Alzheimer’s disease (AD) and cancer reported in
epidemiological studies remains poorly understood. We injected melanoma B16F0 cells or saline into 5xFAD transgenic AD mice and wildtype (WT) controls and monitored tumor growth and cognitive performance (Y maze, Oasis maze) over 28 days. Melanoma- inoculated 5xFAD mice (5xFAD/B16F0) demonstrated improved cognition compared to 5xFAD/saline, regardless of tumor development, suggesting a systemic immune effect rather than one driven by tumor growth. 5xFAD/B16F0 mice also showed reduced tumor incidence than WT mice, as well as an increased number of splenic myeloid cells. Although amyloid-β levels and the number of astrocytes and microglia were unchanged, microglial soma area in the hippocampus was reduced in 5xFAD/B16F0, suggesting a shift toward a less reactive microglial phenotype. These results suggest that peripheral immune activation may modulate microglia in the hippocampus, offering preliminary insights into the biological basis of the AD and cancer inverse relationship.BB performed the experiments and analyzed, and interpreted the data regarding the
experimental studies of cognitive behavior and neuropathological experiments, and was a major contributor in the writing of the manuscript. JM performed the experiments and analyzed and interpreted the data regarding the experimental studies of cognitive behavior and neuropathological experiments, and was a major contributor in the writing of the manuscript. DPP managed the experimental design and analyzed and interpreted the results. CDA contributed to the determination of amyloid staining and analyzed and interpreted the data. PL contributed to the analysis and quantification of amyloid plaque staining. AG performed the immunological analysis in the brains and spleens of transgenic and WT mice. FT performed immunological analysis on the brains and spleens of transgenic and WT mice. FS contributed to the conceptual design of the study and the analysis of the results. MP contributed to the determination of amyloid staining. CSM contributed to the conceptual design of the research and analysis of the results. MC contributed to the conceptual design of the research and analysis of the results. AFGQ contributed to the conceptual design of the research and analysis of the results, ML contributed to the analytic discussion of the immunological results. FS-O contributed to the analytic discussion of the immunological results and text revision. MIB contributed to the experimental design, analysis, and interpretation of the results, and was a major contributor to the writing of the manuscript. All authors read and approved the final manuscript.