Effects of Nicotine Exposure and Delay-Exposure Training on Suboptimal Choice in Ratshttps://doi.org/10.34691/UCHILE/TDZQU9Parrado , Felipe ErnestoMiguez, GonzaloSilva, Matías FFuentealba, Catalina FernandaLaborda, MarioQuezada, VanetzaRepositorio de datos de investigación de la Universidad de Chile2026-04-132026-04-13T17:05:58ZFONDECYT 3240295. The literature suggests that nicotine accelerates the 'internal clock,' increasing preference for immediate rewards and altering sensitivity to discriminative cues associated with delayed consequences. This experiment evaluated whether a behavioral training procedure based on exposure to delays could buffer the impact of vaporized nicotine on decision-making. In this study, 24 rats (both females and males) learned to operate a lever at different intervals to obtain rewards, simulating situations in which it is necessary to choose between a sooner reward or a larger but delayed one over a period of six weeks. Subsequently, half of the groups were passively exposed to 0 mg/L (CN) or 3 mg/L (EX) of nicotine for 15 minutes, followed by training in a chained-choice task with optimal and suboptimal alternatives for two weeksSocial Sciences2026-04-13Parrado , Felipe Ernesto2025-12-12CC-BY 4.0