Effects of Nicotine Exposure and Delay-Exposure Training on Suboptimal Choice in Ratsdoi:10.34691/UCHILE/TDZQU9Repositorio de datos de investigación de la Universidad de Chile2026-04-131Parrado , Felipe Ernesto; Miguez, Gonzalo; Silva, Matías F; Fuentealba, Catalina Fernanda; Laborda, Mario; Quezada, Vanetza, 2026, "Effects of Nicotine Exposure and Delay-Exposure Training on Suboptimal Choice in Rats", https://doi.org/10.34691/UCHILE/TDZQU9, Repositorio de datos de investigación de la Universidad de Chile, V1Effects of Nicotine Exposure and Delay-Exposure Training on Suboptimal Choice in RatsPosdoctoral FONDECYT 3240295doi:10.34691/UCHILE/TDZQU9Parrado , Felipe ErnestoMiguez, GonzaloSilva, Matías FFuentealba, Catalina FernandaLaborda, MarioQuezada, VanetzaRepositorio de datos de investigación de la Universidad de ChileParrado , Felipe ErnestoParrado , Felipe Ernesto2025-12-12Social SciencesFONDECYT 3240295. The literature suggests that nicotine accelerates the 'internal clock,' increasing preference for immediate rewards and altering sensitivity to discriminative cues associated with delayed consequences. This experiment evaluated whether a behavioral training procedure based on exposure to delays could buffer the impact of vaporized nicotine on decision-making. In this study, 24 rats (both females and males) learned to operate a lever at different intervals to obtain rewards, simulating situations in which it is necessary to choose between a sooner reward or a larger but delayed one over a period of six weeks. Subsequently, half of the groups were passively exposed to 0 mg/L (CN) or 3 mg/L (EX) of nicotine for 15 minutes, followed by training in a chained-choice task with optimal and suboptimal alternatives for two weeksNicotineDelayChoice.zipData output and R scriptsapplication/zip