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Barbara Bruna Jara; Jamileth More; Pedro Lobos Zambrano; Daniela Paz Ponce de la Vega; Claudia Duran-Aniotz; Jose Luis Valdés; Maria Alejandra Gleisner; Fabian Tempio; Felipe Salech; Matías Pizarro; Carol D SanMartín; Martín Cárcamo; Andrew Quest; Mercedes Lopez; Flavio Salazar O; Maria Isabel Behrens, 2025, "Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model of Alzheimer’s disease", https://doi.org/10.34691/UCHILE/UYC3UR, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:nVCODfzbWscGFgmS53OoYA== [fileUNF]
The inverse association between Alzheimer’s disease (AD) and cancer reported in epidemiological studies remains poorly understood. We injected melanoma B16F0 cells or saline into 5xFAD transgenic AD mice and wildtype (WT) controls and monitored tumor growth and cognitive performa... |
19 abr. 2023
Hetz, Claudio; Duran-Aniotz, Claudia; Rivera-Krstulovic, Catalina; Poblete, Natalia; Ardiles, Alvaro O.; Sabusap, Carleen; Gerakis, Yannis; Cabral Miranda, Felipe; Diaz, Javier; Fuentealba, Matias; Muño, Ernesto; Espinosa, Sandra; Martinez, Gabriela; Quiroz, Gabriel; Tamburini, Giovanni; Medinas, Danilo B.; Contreras, Darwin; Piña, Ricardo; Lourenci, Mychael; Figueiredo, Claudia; Ferreira, Sergio; Rozas, Carlos; Morales, Bernardo; Plate, Lars; Gonzalez-Billault, Christian; Palacios, Adrian, 2021, "The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis", https://doi.org/10.34691/FK2/VUWSYP, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:SCI3Lz4cZaT9RodbHbGDFg== [fileUNF]
Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer´s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main signaling pathway emerging from the ER to cope wi... |
