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1 a 10 de 14 Resultados

Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models 19 jul. 2024 Hetz, Claudio; Mei Li Diaz; Diego Arriagada; Giovanni Tamburini; Natalia Poblete; Alvaro Ardiles; David Neira; Denisse Sepulveda; Gabriela Martinez; Els Henckaerts; Julie Tordo; Sergio T. Ferreira; Adrian G. Palacios; Marcia Weber, 2024, "Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models", https://doi.org/10.34691/UCHILE/IAE3N6, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:x5ZPoCTpoVEyN5PY+SQZTQ== [fileUNF] Proteostasis impairment at the level of the endoplasmic reticulum (ER) is a salient feature of Alzheimer’s disease (AD). The unfolded protein response (UPR) is the main adaptive pathway to cope with protein folding stress at the ER, where the expression of the transcription facto...
Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice 18 jul. 2024 Hetz, Claudio; Danilo B. Medinas; Juan Pablo Henriquez; Ute Woehlbier; Bredford Kerr; Guillermo Diaz; Amparo Zuleta; Matías Mansilla-Jaramillo; Pablo Rozas; Jessica Mella; Jorge Ojeda; Viviana Perez; Patricia Ojeda; Francisca Martinez-Traub1; Martin Sepulveda, 2024, "Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice", https://doi.org/10.34691/UCHILE/Z9SEHC, Repositorio de datos de investigación de la Universidad de Chile, V2 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motoneurons and compromised proteostasis. Dysfunction of the endoplasmic reticulum (ER) has been identified as a transversal pathogenic mechanism associated to motoneurons vulnerabil...
Perceived Nutrition Environment Measures Survey - Chile (NEMS-P-Ch) 9 jul. 2024 Egaña, Daniel; Rodríguez-Osiac, Lorena; Molina, Paulina; Gálvez, Patricia; Villagas, Rodrigo, 2023, "Perceived Nutrition Environment Measures Survey - Chile (NEMS-P-Ch)", https://doi.org/10.34691/UCHILE/9HKSDP, Repositorio de datos de investigación de la Universidad de Chile, V3, UNF:6:1R7lmoVKj1KV+OIzcRP43Q== [fileUNF] Los datos aquí contenidos responden al proyecto FONIS “Evaluando ambientes alimentarios desde el hogar: una contribución a las políticas locales". Los distintos archivos se asocian a diferentes publicaciones.
Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD. 30 may. 2024 Hetz, Claudio; Vicente Valenzuela; Daniela Becerra; José Astorga; Matias Fuentealba; Guillermo Diaz; Leslie Bargsted; Carlos Chacón; Alexis Martinez; Romina Gozalvo; Kasey Jackson; Vania Morales; Macarena Las Heras; Giovanni Tamburini; Leonard Petrucelli; Pablo Sardi; Lars Plate, 2024, "Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.", https://doi.org/10.34691/UCHILE/4MDLCP, Repositorio de datos de investigación de la Universidad de Chile, V2 Data used for Research Article submission to Molecular Therapy Journal for review Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) are part of a spectrum of diseases that share several causative genes, resulting on a combinatory of motor and cognitive sympto...
Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria 24 may. 2024 Sebastian Delgado; Álvaro Armijo; Verónica Bravo; Omar Orellana; Juan Carlos Salazar; Assaf Katz, 2024, "Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria", https://doi.org/10.34691/UCHILE/AYDRZL, Repositorio de datos de investigación de la Universidad de Chile, V3, UNF:6:H4RkW4KY33+u8SKNSXXA8A== [fileUNF] The data presented here corresponds to the supplementary data of the article entitled "Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria" by Delgado et al. It contains supplementary figures, supplemntary...
Manual de aplicación e interpretación del instrumento NEMS-P-Ch 9 nov. 2023 Daniel Egaña Rojas; Lorena Rodríguez Osiac; Patricia Gálvez Espinoza; Paulina Molina Carrasco; Rodrigo Villegas Ríos; Bárbara Castillo Villalobos, 2023, "Manual de aplicación e interpretación del instrumento NEMS-P-Ch", https://doi.org/10.34691/UCHILE/ILTLIV, Repositorio de datos de investigación de la Universidad de Chile, V1, UNF:6:mdbBL75/15Aoi5Mp0qjD3A== [fileUNF] El presente manual tiene por objetivo ser una guía práctica para el trabajo de campo cuando se aplique el instrumento NEMS-P-Ch, cuestionario que ha sido previamente testeado y validado en Chile . Este instrumento evalúa las percepciones de los ambientes alimentarios de los sujet...
Replication Data for: "The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures" 20 abr. 2023 Juricic, María de los Ángeles; Gallardo, Javiera; Cerda, Mauricio; Couve, Andrés; Hartel, Steffen; González, Carolina, 2021, "Replication Data for: "The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures"", https://doi.org/10.34691/FK2/SX58LI, Repositorio de datos de investigación de la Universidad de Chile, V2 The ER-to-Golgi intermediate compartment (ERGIC) is a membranous organelle that mediates protein transport between the endoplasmic reticulum (ER) and Golgi apparatus. In neurons, clusters of these vesiculotubular structures are situated in throughout the cell in proximity to the...
Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes: Dipsadidae) 19 abr. 2023 Reyes-Olivares, Claudio; Vera-Quispe, Alex; Zúñiga, Alejandro; Urra, Felix, 2022, "Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes: Dipsadidae)", https://doi.org/10.34691/FK2/VSB4D4, Repositorio de datos de investigación de la Universidad de Chile, V2 Several aspects of the antipredatory behaviour of the South American rear-fanged snakes Tachymenis peruviana and T. chilensis coronellina remain still uncertain. In this work, we describe the first records of head-wobble behaviour for T. peruviana and T. ch. coronellina, obtained...
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis 19 abr. 2023 Hetz, Claudio; Duran-Aniotz, Claudia; Rivera-Krstulovic, Catalina; Poblete, Natalia; Ardiles, Alvaro O.; Sabusap, Carleen; Gerakis, Yannis; Cabral Miranda, Felipe; Diaz, Javier; Fuentealba, Matias; Muño, Ernesto; Espinosa, Sandra; Martinez, Gabriela; Quiroz, Gabriel; Tamburini, Giovanni; Medinas, Danilo B.; Contreras, Darwin; Piña, Ricardo; Lourenci, Mychael; Figueiredo, Claudia; Ferreira, Sergio; Rozas, Carlos; Morales, Bernardo; Plate, Lars; Gonzalez-Billault, Christian; Palacios, Adrian, 2021, "The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis", https://doi.org/10.34691/FK2/VUWSYP, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:SCI3Lz4cZaT9RodbHbGDFg== [fileUNF] Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer´s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main signaling pathway emerging from the ER to cope wi...
Supplementary Figure 1: (A-B) Stillbirths and (C-D) neonates of Philodryas chamissonis in individual containers 11 abr. 2023 Cabeza, Osvaldo; Vargas, Eugenio; Ibarra, Carolina; Urra, Félix A., 2019, "Supplementary Figure 1: (A-B) Stillbirths and (C-D) neonates of Philodryas chamissonis in individual containers", https://doi.org/10.34691/FK2/IL1VMH, Repositorio de datos de investigación de la Universidad de Chile, V1 Supplementary Figure 1

Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models

19 jul. 2024

Hetz, Claudio; Mei Li Diaz; Diego Arriagada; Giovanni Tamburini; Natalia Poblete; Alvaro Ardiles; David Neira; Denisse Sepulveda; Gabriela Martinez; Els Henckaerts; Julie Tordo; Sergio T. Ferreira; Adrian G. Palacios; Marcia Weber, 2024, "Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models", https://doi.org/10.34691/UCHILE/IAE3N6, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:x5ZPoCTpoVEyN5PY+SQZTQ== [fileUNF]

Proteostasis impairment at the level of the endoplasmic reticulum (ER) is a salient feature of Alzheimer’s disease (AD). The unfolded protein response (UPR) is the main adaptive pathway to cope with protein folding stress at the ER, where the expression of the transcription facto...

Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice

18 jul. 2024

Hetz, Claudio; Danilo B. Medinas; Juan Pablo Henriquez; Ute Woehlbier; Bredford Kerr; Guillermo Diaz; Amparo Zuleta; Matías Mansilla-Jaramillo; Pablo Rozas; Jessica Mella; Jorge Ojeda; Viviana Perez; Patricia Ojeda; Francisca Martinez-Traub1; Martin Sepulveda, 2024, "Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice", https://doi.org/10.34691/UCHILE/Z9SEHC, Repositorio de datos de investigación de la Universidad de Chile, V2

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motoneurons and compromised proteostasis. Dysfunction of the endoplasmic reticulum (ER) has been identified as a transversal pathogenic mechanism associated to motoneurons vulnerabil...

Perceived Nutrition Environment Measures Survey - Chile (NEMS-P-Ch)

9 jul. 2024

Egaña, Daniel; Rodríguez-Osiac, Lorena; Molina, Paulina; Gálvez, Patricia; Villagas, Rodrigo, 2023, "Perceived Nutrition Environment Measures Survey - Chile (NEMS-P-Ch)", https://doi.org/10.34691/UCHILE/9HKSDP, Repositorio de datos de investigación de la Universidad de Chile, V3, UNF:6:1R7lmoVKj1KV+OIzcRP43Q== [fileUNF]

Los datos aquí contenidos responden al proyecto FONIS “Evaluando ambientes alimentarios desde el hogar: una contribución a las políticas locales". Los distintos archivos se asocian a diferentes publicaciones.

Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.

30 may. 2024

Hetz, Claudio; Vicente Valenzuela; Daniela Becerra; José Astorga; Matias Fuentealba; Guillermo Diaz; Leslie Bargsted; Carlos Chacón; Alexis Martinez; Romina Gozalvo; Kasey Jackson; Vania Morales; Macarena Las Heras; Giovanni Tamburini; Leonard Petrucelli; Pablo Sardi; Lars Plate, 2024, "Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.", https://doi.org/10.34691/UCHILE/4MDLCP, Repositorio de datos de investigación de la Universidad de Chile, V2

Data used for Research Article submission to Molecular Therapy Journal for review Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) are part of a spectrum of diseases that share several causative genes, resulting on a combinatory of motor and cognitive sympto...

Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria

24 may. 2024

Sebastian Delgado; Álvaro Armijo; Verónica Bravo; Omar Orellana; Juan Carlos Salazar; Assaf Katz, 2024, "Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria", https://doi.org/10.34691/UCHILE/AYDRZL, Repositorio de datos de investigación de la Universidad de Chile, V3, UNF:6:H4RkW4KY33+u8SKNSXXA8A== [fileUNF]

The data presented here corresponds to the supplementary data of the article entitled "Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria" by Delgado et al. It contains supplementary figures, supplemntary...

Manual de aplicación e interpretación del instrumento NEMS-P-Ch

9 nov. 2023

Daniel Egaña Rojas; Lorena Rodríguez Osiac; Patricia Gálvez Espinoza; Paulina Molina Carrasco; Rodrigo Villegas Ríos; Bárbara Castillo Villalobos, 2023, "Manual de aplicación e interpretación del instrumento NEMS-P-Ch", https://doi.org/10.34691/UCHILE/ILTLIV, Repositorio de datos de investigación de la Universidad de Chile, V1, UNF:6:mdbBL75/15Aoi5Mp0qjD3A== [fileUNF]

El presente manual tiene por objetivo ser una guía práctica para el trabajo de campo cuando se aplique el instrumento NEMS-P-Ch, cuestionario que ha sido previamente testeado y validado en Chile . Este instrumento evalúa las percepciones de los ambientes alimentarios de los sujet...

Replication Data for: "The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures"

20 abr. 2023

Juricic, María de los Ángeles; Gallardo, Javiera; Cerda, Mauricio; Couve, Andrés; Hartel, Steffen; González, Carolina, 2021, "Replication Data for: "The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures"", https://doi.org/10.34691/FK2/SX58LI, Repositorio de datos de investigación de la Universidad de Chile, V2

The ER-to-Golgi intermediate compartment (ERGIC) is a membranous organelle that mediates protein transport between the endoplasmic reticulum (ER) and Golgi apparatus. In neurons, clusters of these vesiculotubular structures are situated in throughout the cell in proximity to the...

Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes: Dipsadidae)

19 abr. 2023

Reyes-Olivares, Claudio; Vera-Quispe, Alex; Zúñiga, Alejandro; Urra, Felix, 2022, "Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes: Dipsadidae)", https://doi.org/10.34691/FK2/VSB4D4, Repositorio de datos de investigación de la Universidad de Chile, V2

Several aspects of the antipredatory behaviour of the South American rear-fanged snakes Tachymenis peruviana and T. chilensis coronellina remain still uncertain. In this work, we describe the first records of head-wobble behaviour for T. peruviana and T. ch. coronellina, obtained...

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis

19 abr. 2023

Hetz, Claudio; Duran-Aniotz, Claudia; Rivera-Krstulovic, Catalina; Poblete, Natalia; Ardiles, Alvaro O.; Sabusap, Carleen; Gerakis, Yannis; Cabral Miranda, Felipe; Diaz, Javier; Fuentealba, Matias; Muño, Ernesto; Espinosa, Sandra; Martinez, Gabriela; Quiroz, Gabriel; Tamburini, Giovanni; Medinas, Danilo B.; Contreras, Darwin; Piña, Ricardo; Lourenci, Mychael; Figueiredo, Claudia; Ferreira, Sergio; Rozas, Carlos; Morales, Bernardo; Plate, Lars; Gonzalez-Billault, Christian; Palacios, Adrian, 2021, "The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis", https://doi.org/10.34691/FK2/VUWSYP, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:SCI3Lz4cZaT9RodbHbGDFg== [fileUNF]

Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer´s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main signaling pathway emerging from the ER to cope wi...

Supplementary Figure 1: (A-B) Stillbirths and (C-D) neonates of Philodryas chamissonis in individual containers

11 abr. 2023

Cabeza, Osvaldo; Vargas, Eugenio; Ibarra, Carolina; Urra, Félix A., 2019, "Supplementary Figure 1: (A-B) Stillbirths and (C-D) neonates of Philodryas chamissonis in individual containers", https://doi.org/10.34691/FK2/IL1VMH, Repositorio de datos de investigación de la Universidad de Chile, V1

Supplementary Figure 1

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