1 a 10 de 134 Resultados
19 jul. 2024
Hetz, Claudio; Mei Li Diaz; Diego Arriagada; Giovanni Tamburini; Natalia Poblete; Alvaro Ardiles; David Neira; Denisse Sepulveda; Gabriela Martinez; Els Henckaerts; Julie Tordo; Sergio T. Ferreira; Adrian G. Palacios; Marcia Weber, 2024, "Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models", https://doi.org/10.34691/UCHILE/IAE3N6, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:x5ZPoCTpoVEyN5PY+SQZTQ== [fileUNF]
Proteostasis impairment at the level of the endoplasmic reticulum (ER) is a salient feature of Alzheimer’s disease (AD). The unfolded protein response (UPR) is the main adaptive pathway to cope with protein folding stress at the ER, where the expression of the transcription facto... |
18 jul. 2024
Hetz, Claudio; Danilo B. Medinas; Juan Pablo Henriquez; Ute Woehlbier; Bredford Kerr; Guillermo Diaz; Amparo Zuleta; Matías Mansilla-Jaramillo; Pablo Rozas; Jessica Mella; Jorge Ojeda; Viviana Perez; Patricia Ojeda; Francisca Martinez-Traub1; Martin Sepulveda, 2024, "Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice", https://doi.org/10.34691/UCHILE/Z9SEHC, Repositorio de datos de investigación de la Universidad de Chile, V2
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motoneurons and compromised proteostasis. Dysfunction of the endoplasmic reticulum (ER) has been identified as a transversal pathogenic mechanism associated to motoneurons vulnerabil... |
18 jul. 2024 -
Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice
application/x-graphpad-prism-pzfx - 162.6 KB -
MD5: 1c9f21e5d53a209b75c46b84edf8e8dd
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18 jul. 2024 -
Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice
MS Powerpoint - 110.8 MB -
MD5: d03d776cb9aef534bae4d824a38cfe66
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18 jul. 2024 -
Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice
MS Excel Spreadsheet - 638.7 KB -
MD5: 5f44e6fc6de8a577eada148ee6c07a40
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application/x-graphpad-prism-pzfx - 30.3 KB -
MD5: 44887a28616139ea6ea757cb8c582bfe
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application/x-graphpad-prism-pzfx - 177.0 KB -
MD5: 1c5de3afe4af3e814e642a0682c358fd
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application/x-graphpad-prism-pzfx - 442.0 KB -
MD5: 24f7a96c2d1a934642345dab494deedb
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MS Word - 6.2 MB -
MD5: fbbc40f475a2efd19ab5beb0977705e0
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MS Powerpoint - 115.5 MB -
MD5: ffd2b0b1f196986b03b0c078f004fedc
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