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1 a 4 de 4 Resultados
Hetz, Claudio; Mei Li Diaz; Diego Arriagada; Giovanni Tamburini; Natalia Poblete; Alvaro Ardiles; David Neira; Denisse Sepulveda; Gabriela Martinez; Els Henckaerts; Julie Tordo; Sergio T. Ferreira; Adrian G. Palacios; Marcia Weber, 2024, "Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models", https://doi.org/10.34691/UCHILE/IAE3N6, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:x5ZPoCTpoVEyN5PY+SQZTQ== [fileUNF]
Proteostasis impairment at the level of the endoplasmic reticulum (ER) is a salient feature of Alzheimer’s disease (AD). The unfolded protein response (UPR) is the main adaptive pathway to cope with protein folding stress at the ER, where the expression of the transcription facto... |
18 jul. 2024 - Facultad de Medicina
Hetz, Claudio; Danilo B. Medinas; Juan Pablo Henriquez; Ute Woehlbier; Bredford Kerr; Guillermo Diaz; Amparo Zuleta; Matías Mansilla-Jaramillo; Pablo Rozas; Jessica Mella; Jorge Ojeda; Viviana Perez; Patricia Ojeda; Francisca Martinez-Traub1; Martin Sepulveda, 2024, "Expression of a protein disulfide isomerase A3 variant associated to amyotrophic lateral sclerosis triggers disease features in mice", https://doi.org/10.34691/UCHILE/Z9SEHC, Repositorio de datos de investigación de la Universidad de Chile, V2
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motoneurons and compromised proteostasis. Dysfunction of the endoplasmic reticulum (ER) has been identified as a transversal pathogenic mechanism associated to motoneurons vulnerabil... |
30 may. 2024 - Facultad de Medicina
Hetz, Claudio; Vicente Valenzuela; Daniela Becerra; José Astorga; Matias Fuentealba; Guillermo Diaz; Leslie Bargsted; Carlos Chacón; Alexis Martinez; Romina Gozalvo; Kasey Jackson; Vania Morales; Macarena Las Heras; Giovanni Tamburini; Leonard Petrucelli; Pablo Sardi; Lars Plate, 2024, "Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.", https://doi.org/10.34691/UCHILE/4MDLCP, Repositorio de datos de investigación de la Universidad de Chile, V2
Data used for Research Article submission to Molecular Therapy Journal for review Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) are part of a spectrum of diseases that share several causative genes, resulting on a combinatory of motor and cognitive sympto... |
19 abr. 2023 - Facultad de Medicina
Hetz, Claudio; Duran-Aniotz, Claudia; Rivera-Krstulovic, Catalina; Poblete, Natalia; Ardiles, Alvaro O.; Sabusap, Carleen; Gerakis, Yannis; Cabral Miranda, Felipe; Diaz, Javier; Fuentealba, Matias; Muño, Ernesto; Espinosa, Sandra; Martinez, Gabriela; Quiroz, Gabriel; Tamburini, Giovanni; Medinas, Danilo B.; Contreras, Darwin; Piña, Ricardo; Lourenci, Mychael; Figueiredo, Claudia; Ferreira, Sergio; Rozas, Carlos; Morales, Bernardo; Plate, Lars; Gonzalez-Billault, Christian; Palacios, Adrian, 2021, "The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis", https://doi.org/10.34691/FK2/VUWSYP, Repositorio de datos de investigación de la Universidad de Chile, V2, UNF:6:SCI3Lz4cZaT9RodbHbGDFg== [fileUNF]
Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer´s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main signaling pathway emerging from the ER to cope wi... |
