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Dec 30, 2021 - Facultad de Medicina
Hetz, Claudio;Duran-Aniotz, Claudia;Rivera-Krstulovic, Catalina;Poblete, Natalia;Ardiles, Alvaro O.;Sabusap, Carleen;Gerakis, Yannis;Cabral Miranda, Felipe;Diaz, Javier;Fuentealba, Matias;Muño, Ernesto;Espinosa, Sandra;Martinez, Gabriela;Quiroz, Gabriel;Tamburini, Giovanni;Medinas, Danilo B.;Contreras, Darwin.;Piña, Ricardo;Lourenci, Mychael;Figueiredo, Claudia;Ferreira, Sergio;Rozas, Carlos;Morales, Bernardo;Plate, Lars;Gonzalez-Billault, Christian;Palacios, Adrian, 2021, "The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis", https://doi.org/10.34691/FK2/VUWSYP, Repositorio de datos de investigación de la Universidad de Chile, V1, UNF:6:r9M5ATdSmQiDiuHAZ7LBPA== [fileUNF]
Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer´s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main signaling pathway emerging from the ER to cope wi...
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