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Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
17 jun. 2024 - Facultad de Medicina
Hetz, Claudio; Diego Arriagada; Giovanni Tamburini; Natalia Poblete; Alvaro Ardiles; David Neira; Denisse Sepulveda; Gabriela Martinez; Els Henckaerts; Julie Tordo; Sergio T. Ferreira; Adrian G. Palacios, 2024, "Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models", https://doi.org/10.34691/UCHILE/IAE3N6, Repositorio de datos de investigación de la Universidad de Chile, V1, UNF:6:x5ZPoCTpoVEyN5PY+SQZTQ== [fileUNF]
Abstract Proteostasis impairment at the level of the endoplasmic reticulum (ER) is a salient feature of Alzheimer’s disease (AD). The unfolded protein response (UPR) is the main adaptive pathway to cope with protein folding stress at the ER, where the expression of the transcript...
Magnitude TBS Aged.tab
17 jun. 2024 - Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Datos tabulares - 1002 B - 10 Variables, 22 Observaciones - UNF:6:mjy4vTV73EXbwzsw+XN81g==
Magnitude TBS Young.tab
17 jun. 2024 - Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Datos tabulares - 682 B - 7 Variables, 12 Observaciones - UNF:6:k67QY8E5IergBPBRTECvjg==
Tabla diferencias proteostaser.tab
17 jun. 2024 - Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Datos tabulares - 252 B - 3 Variables, 7 Observaciones - UNF:6:5VQxdQ75zRkOHrghGl9GPg==
WB GFP.tab
17 jun. 2024 - Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Datos tabulares - 287 B - 4 Variables, 6 Observaciones - UNF:6:13bqvFGvLQIjuiv748qPfA==
raw data tbs Aged.tab
17 jun. 2024 - Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Datos tabulares - 10.4 KB - 24 Variables, 79 Observaciones - UNF:6:5FIxxdG4NTqOoNiuiQKcWQ==
raw data tbs young.tab
17 jun. 2024 - Optimized adeno-associated vector to deliver the unfolded protein response transcription factor XBP1s into the hippocampus ameliorates Alzheimer’s disease features in mouse models
Datos tabulares - 15.7 KB - 29 Variables, 78 Observaciones - UNF:6:OM/2bWsxraB9qIChCcIkkQ==
Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.
30 may. 2024 - Facultad de Medicina
Hetz, Claudio; Vicente Valenzuela; Daniela Becerra; José Astorga; Matias Fuentealba; Guillermo Diaz; Leslie Bargsted; Carlos Chacón; Alexis Martinez; Romina Gozalvo; Kasey Jackson; Vania Morales; Macarena Las Heras; Giovanni Tamburini; Leonard Petrucelli; Pablo Sardi; Lars Plate, 2024, "Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.", https://doi.org/10.34691/UCHILE/4MDLCP, Repositorio de datos de investigación de la Universidad de Chile, V2
Data used for Research Article submission to Molecular Therapy Journal for review Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) are part of a spectrum of diseases that share several causative genes, resulting on a combinatory of motor and cognitive sympto...
Compiled_supplementary_figures.pdf
24 may. 2024 - Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria
Adobe PDF - 73.8 MB - MD5: 8cf4a8c93d90d523fbb4aef895d44c0a
A file that compiles all supplementary figures of the paper in a single file
Legends for supplementary figures and tables.pdf
24 may. 2024 - Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria
Adobe PDF - 71.0 KB - MD5: 99bd31ffc675a92186a783ebcc1c8556
Description of filesDocumentaciónSupplementary FigureSupplementary Table
Contains a list of figures and tables included in the dataset with their corresponding description. Please refer to "README.pdf" for a list and description of the scripts included in this dataset.
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